Usability and Design of Personal Wearable and Portable Devices for Thermal Comfort

Conference paperPersonal comfort is important in the design of objects and environments. However, as comfort is a subjective experience, it is a very difficult aspect to design for. This paper presents an interrogation into the design for human thermal comfort, in particular the design of personal devices for use in shared work environments. The findings of two user studies are presented, in which wearable and portable, off-the-shelf personal heating and cooling devices were deployed in the field to explore the interaction with and use of these devices in everyday settings with the aim to uncover key aspects and requirements for the design of such devices. We found that functionality and affordances, i.e. the design for versatility, appropriation and mobility, as well as control, availability, effectiveness and efficiency of use were most important. Furthermore, individual preferences, foremost the preference for on-body versus off-body heating and cooling, and aspects related to wearable design of the devices, such as aesthetics, materiality, comfort of wear, mobility and unobtrusiveness, also need to be taken into account.This research was supported by the Media & Arts Technology Programme at the School of Electronic Engineering and Computer Science, Queen Mary University of London, an EPSRC Centre for Doctoral Training (EP/G03723X/1)

Assessing Comfort in Open-Plan Offices on Campus – Which Comfort Parameters Matter?

PosterComfort is a highly individual and adaptive process, which is influenced by a multitude of environmental and social factors. In the scope of a pilot study, we conducted an online survey among PhD students, most of whom have desk spaces assigned in open-plan offices on campus, to uncover issues affecting their comfort from an individual perspective based on quantitative as well as qualitative information. We found that social aspects were cited most often as positive qualities of the workplace, whereas environmental factors were most often cited as sources of discomfort, with thermal and acoustic discomfort as well as matters of cleanliness leading the way. Participants indicated that some of these parameters also influenced their use or avoidance of their workplace, which reflected in their frequency of use and the use of other places to work. We consequently identified decision making processes based on indoor environmental quality parameters taking place in the choice of a work place as a possible area for further investigation, which could include looking at activity and work patterns alongside individual preferences.This work is supported by the Media & Arts Technology Programme, an EPSRC Doctoral Training Centre at Queen Mary University of London (EP/G03723X/1)

Charged-Lepton Flavour Physics

This writeup of a talk at the 2011 Lepton-Photon symposium in Mumbai, India, summarises recent results in the charged-lepton flavour sector. I review searches for charged-lepton flavour violation, lepton electric dipole moments and flavour-conserving CP violation. I also discuss recent progress in tau-lepton physics and in the Standard Model prediction of the muon anomalous magnetic moment.Comment: Presented at Lepton-Photon 2011, Mumbai, India; 23 pages, 14 figure

Weinberg like sum rules revisited

The generalized Weinberg sum rules containing the difference of isovector vector and axial-vector spectral functions saturated by both finite and infinite number of narrow resonances are considered. We summarize the status of these sum rules and analyze their overall agreement with phenomenological Lagrangians, low-energy relations, parity doubling, hadron string models, and experimental data.Comment: 31 pages, noticed misprints are corrected, references are added, and other minor corrections are mad

Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships

INTRODUCTION: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity, which is required for the ubiquitination of securin and cyclin-B. Moreover, the mitotic spindle checkpoint is activated if APC activation is prevented. In addition, several APC-targeting molecules such as securin, polo-like kinase, aurora kinase, and SnoN have been reported to be oncogenes. Therefore, dysregulation of APC may be associated with tumorigenesis. However, the clinical significance and the involvement of APC in tumorigenesis have not been investigated. METHODS: The expression of APC7 was immunohistochemically investigated in 108 invasive ductal carcinomas of the breast and its relationship with clinicopathologic parameters was examined. The expression of APC7 was defined as positive when the summed scores of staining intensities (0 to 3+) and stained proportions (0 to 3+) exceeded 3+. RESULTS: Positive APC7 expression was less frequent than its negative expression when histologic (P = 0.009) or nuclear grade (P = 0.009), or mitotic number (P = 0.0016) was elevated. The frequency of APC7 negative expression was higher in high Ki-67 or aneuploid groups than in low Ki-67 or diploid groups. CONCLUSION: These data show that loss of APC7 expression is more common in breast carcinoma cases with poor prognostic parameters or malignant characteristics. They therefore suggest that dysregulation of APC activity, possibly through downregulation of APC7, may be associated with tumorigenesis in breast cancer

A strategy to discover new organizers identifies a putative heart organizer

Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer. We show that the AIP can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying ventricular and suppressing atrial regional identity. We also uncover some of the signals responsible. The method holds promise as a tool to discover other novel organizers acting during development

QCD and strongly coupled gauge theories : challenges and perspectives

We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe